Questions List

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Are genetic causes the main reason for early prgnancy lossPosted onOctober 21, 2020 9:18 am

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What do indications for PGD?Posted onSeptember 28, 2020 5:44 am

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Is the conference recordedPosted onSeptember 26, 2020 3:11 pm

Dr Adi- What is the protocol for the evaluation of POI in females?Posted onSeptember 26, 2020 2:34 pm

To Dr Adi Reches- Do we advice egg preservation in FMR1 premutation carrier females? Doesn't it at risk of triplet repeat expansion?Posted onSeptember 26, 2020 2:28 pm

@ Dr. Morena- So does that mean we need to advice lactovit intake to improve female genital microbiome?Posted onSeptember 26, 2020 2:26 pm

Dr Moreno, nice presentation. Thank you. Do you treat or suggest treating infertile/RPL patients with Lactobacilli? Posted onSeptember 26, 2020 2:25 pm

Nice presentation. Do you advise women taking probiotics to improve endometrial microbiome?Posted onSeptember 26, 2020 2:24 pm

I am having issues with live streaming . Anyonelse?Posted onSeptember 26, 2020 2:17 pm

I am having issues with live streaming . Anyonelse?Posted onSeptember 26, 2020 2:16 pm

Posted onSeptember 26, 2020 2:15 pm

Do you believe to be reliable incorporate this screening at non invasive PGT-A? Posted onSeptember 26, 2020 1:42 pm

Please give us a simple as possible, one method to select the most appropiate tecnique for each kind of pregnancy , for example, if there is a pregnancy in a young woman, old woman, without bad history , with positive familiar or personal history, so I understand is a recomendation that we make an extended screening, perhaps to all population(??)Posted onSeptember 26, 2020 1:25 pm

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whole genome sequencing and exome sequencing which one is superior in regards to developing prenatal diagnosis?Posted onSeptember 26, 2020 1:08 pm

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@ Dr Belmont: What is your experience in use of WGS for detecting triplet repeats?Posted onSeptember 26, 2020 1:03 pm

I am obstetrician, can new born with mutation in OPA1 GENE PRESENT WITH NEONATAL ENCEPHALOPATHY Posted onSeptember 26, 2020 1:01 pm

@ Dr Levy: Thanks for the talk. was postnatal phenotyping done for all 460 cases? If yes, did it reveal more variants or change diagnosis?Posted onSeptember 26, 2020 12:58 pm

@ Dr Levy: Thanks for the talk. was postnatal phenotyping done for all 460 cases? If yes, did it reveal more variants or change diagnosis?Posted onSeptember 26, 2020 12:58 pm

Fine with Exome or Genome sequencing - but what about investigating epigenetics and transcriptomics changes to add value?Posted onSeptember 26, 2020 12:48 pm

Thanks for the overview. Is DECIPHER consent asked and w ill the results be shared with DECIPHER?Posted onSeptember 26, 2020 12:41 pm

*************** Session 3 ************************* Posted onSeptember 26, 2020 12:09 pm

@Yuval- What is your take on the relevance of cfDNA analysis in clinical practice for RPL?Posted onSeptember 26, 2020 12:06 pm

@Dr.Beaudet Is there a correlation between cell free fetal fraction and number of fetal cells? Were you able to detect other fetal cell types? Erythroblasts? Posted onSeptember 26, 2020 12:05 pm

@Diane Van Opstal 1. What was the incidence of maternal acquired chromosomal aberrations and the confirmation of malignancy? Is there a recommendation on follow up for these patients? 2. How was the placental mosaicism confirmed? Posted onSeptember 26, 2020 12:05 pm

@Yuval- Till what time of abortion one can do maternal cfDNA analysis for fetal aneuploidies in the case of RPL/EPL? Posted onSeptember 26, 2020 12:02 pm

Which is the real incidence of mosaic in human pregnancy? Posted onSeptember 26, 2020 11:55 am

can we collect fetal exfoliated cells from gravid cervix for cell mediated NIPT.Posted onSeptember 26, 2020 11:50 am

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The analogy to CVS as also being diagnostic is limited because with CVS you understand when amniocentesis followup is necessary. This hasn't been proven to be true with whole fetal trophoblasts.Posted onSeptember 26, 2020 11:49 am

Most of the people are who living in rural areas mostly in African countries not aware of happenings what measures are taken for awareness and educating them Posted onSeptember 26, 2020 11:49 am

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I congratulate you for your this presentation. Thank you so much.Posted onSeptember 26, 2020 11:40 am

To Dr Yaron why don't look for cfDNA from endocervix in pregnancy loss Posted onSeptember 26, 2020 11:34 am

For Dr. Arthur Beaudet: I thought that white cells are more maternal than fetal cells....Do I understood correct? Did You find more fetal cells on white cells? Do you do the test on these cells?Posted onSeptember 26, 2020 11:25 am

Published literature shows cytogenetics can achieve over 90% success and over 80% abnormality. How does this relate to 53%?Posted onSeptember 26, 2020 11:16 am

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Art Beaudet: this looks very promising. Is it cost effective ? can it be scaled up for population –wide screening? Posted onSeptember 26, 2020 11:08 am

How does SCT compare to whole exome sequencing? and to microarray? When performing amniocenteses we are doing at least a microarray and save DNA for exome sequencing. Posted onSeptember 26, 2020 11:08 am

If I listened well you are studying trophoblast cells. You stated that the test is "relatively" diagnostic. But... confined placental mosaicism is an issue here as well isn't it? Hence risk of discrepant positives remains.Posted onSeptember 26, 2020 11:03 am

Do you think that is possible also identify S phase cells on niPGTa? Posted onSeptember 26, 2020 11:01 am

How can testing of the trophoblast cells be considered when diagnostic when mosaicism is a known confounder?Posted onSeptember 26, 2020 11:01 am

Do cells persist from previous pregnancies? What is the cost of this? Posted onSeptember 26, 2020 11:01 am

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For Diane van Opstel: Do you have a sense on what % of women in a broad screening assay would start receiving false positive results vs women who only test for T21, 18, and 13?Posted onSeptember 26, 2020 10:46 am

Your experience and data on additional chromosome anomalies detected via NIPT could be very valuable for the worldwide community. Are you considering opening up your database for scientists and practitioners elsewhere in the world? Posted onSeptember 26, 2020 10:45 am

How many cases of 22q11 deletions were detected in TRIDENT-2?Posted onSeptember 26, 2020 10:45 am

what is your experience about false positives with 21 trisomies?Posted onSeptember 26, 2020 10:43 am

what is your experience about false positives with 21 trisomies?Posted onSeptember 26, 2020 10:43 am

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************** Session 2 ************************** Posted onSeptember 26, 2020 10:32 am

thank you! Posted onSeptember 26, 2020 10:32 am

Since you don’t include ff. Is it advisable to offer this NIPT early in pregnancy is at 10 or 11 wk of gestation?Posted onSeptember 26, 2020 10:32 am

Then we are waiting impationally for a great results) thank you for a great work! Posted onSeptember 26, 2020 10:31 am

Can you test twin pregnancies?Posted onSeptember 26, 2020 10:28 am

I see that one of reason you choose Vanadis is low cost, can you let us know the price of test?Posted onSeptember 26, 2020 10:27 am

Lawrence, would you think it would be better to report on a removed FF if a follow up is not completed? So you cover both bases Posted onSeptember 26, 2020 10:24 am

a question, do you envision expanding the test to include other chromosomes and copy number variants (from Yuval Yaron)Posted onSeptember 26, 2020 10:23 am

Is there any invents or technical features to perform validated NIPT with micro-indels?Posted onSeptember 26, 2020 10:22 am

With this method, it is not necesary to get a n amniotic sample , is it true?Posted onSeptember 26, 2020 10:22 am

Can you talk about the PPV and NPV of Vanadis? Posted onSeptember 26, 2020 10:21 am

Hancock and Muzzey used an NGS based NIPT test and did fail samples in case of low FF with insufficient number of reads, they did not "pass" all samples with low FF. How have you incorporated this in your calculations? Posted onSeptember 26, 2020 10:20 am

what is the TAT for NIPT in your hospital in Italy?Posted onSeptember 26, 2020 10:19 am

I can not enter Posted onSeptember 26, 2020 10:18 am

with vanadis, you do not need to determin FF? Posted onSeptember 26, 2020 10:18 am

Hi, Now I am not connected with this Live. Whats going on? Posted onSeptember 26, 2020 10:18 am

Posted onSeptember 26, 2020 10:18 am

With this method this is no necessary to take an amniotic sample, its true??Posted onSeptember 26, 2020 10:18 am

I would like to ask about the omit FF in report: if you do not consider FF, how to you know that this result is exactly reflect DNA fetus vs mother? As I know that in 2015 there is a paper of Takoudes that show that 2 Labs already returned the wrong result because of wrong FF?Posted onSeptember 26, 2020 10:17 am

I would like to ask about the omit FF in report: if you do not consider FF, how to you know that this result is exactly reflect DNA fetus vs mother? As I know that in 2015 there is a paper of Takoudes that show that 2 Labs already returned the wrong result because of wrong FF?Posted onSeptember 26, 2020 10:17 am

Question to Lawrence. I suppose the implications of removing ff-cut-off are depending on the sensitivity of the NIPT assay, which are often described as being different for the three common trisomies. Did you calculate the effect of lower sensitivity, and might it impact your advice not to use a cut-off? Furthermore, is it your advice to remove the cut-off also for twin pregnancies (dizygotic) Posted onSeptember 26, 2020 10:01 am

I may sound brash but in all politeness I would like to reassert that you recommendation of "Implementation of NIPT screening for all women" is downright unethical, extremely costly to pregnant subjects and in no way justifiable. Instead the present focused testing for high-risk subjects only is most prudent, ethical, sensible and should not be dismantled.Posted onSeptember 26, 2020 10:00 am

I am joining from a country where in 2020 , four million children in India are expected to be born through institutional deliveries, and a little over 277 thousand home births. In that case, by your recommendation about 42,77,000 pregnant subjects would have to be subjected to NIPT testing. This is a conservative estimate as this does not include many other groups. Currently the cost of the testing by double or quadruple markers is about 20 US$ each. This will catapult to about 200 US$ each if NIPT is to be done at the current costing in India. Current trend and recommendation in our country is to confine this testing to high-risk mothers only. This includes mothers like those above 35 years of age &/or showing soft marker risks like high NT, hypoplastic nasal bone and the like. With this recommendation you want to increase the cost by US$769860000 - a humongous astronomical figure annually. Remember in India this cost in most instances is to be borne by the pregnant subject herself. How ethical is your recommendation then? How do you justify this additional burden of US$769860000 (conservative estimates) on the pocket of pregnant mothers? Posted onSeptember 26, 2020 9:55 am

Dear Lawrence Prensky sir, If any available notebook of The 7th CoGEN World Congress on Controversies in Preconception, Preimplantation and Prenatal Genetic Diagnosis (CoGEN).Posted onSeptember 26, 2020 9:47 am

******************** Perkin Elmer *************************Posted onSeptember 26, 2020 9:39 am

Can't hear anything ..Posted onSeptember 26, 2020 9:39 am

Women those who are suffering from cervical cancer can be able to become mother of their own womb Posted onSeptember 26, 2020 9:36 am

After doing PGT-A and PGT-M, is there a need for doing prenatal diagnosis again by amniocentesis or chorionic villus sampling?Posted onSeptember 26, 2020 9:32 am

Beside molecular, what are the features in the mophological aspect of this pgd-t? features we should examine to suggest male or femalePosted onSeptember 26, 2020 9:29 am

To the last speaker all of people mosaic and has a Cancer mutations. What's PPV of PGT-P?Posted onSeptember 26, 2020 9:27 am

Thank you so much for your scientific programs. Posted onSeptember 26, 2020 9:08 am

With the advancement in PGT-A and mosaicism analysis, what are the current major clinical indications for PGT-A?Posted onSeptember 26, 2020 9:07 am

how do you feel about diagnosis and then ET of mafe PGT-M cariers of BRCA? we get some requests like this from couples with no non-carrier PGT-M embyosPosted onSeptember 26, 2020 9:03 am

Question to D.Munne in your opinion what's the minimal reference of kpi like no call rate or IR to get profit from PGTa? Thank youPosted onSeptember 26, 2020 8:46 am

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Which is the best period to find out any genetically defect and how autistic or autism can be found what precautionary measures should be taken during pregnancy Posted onSeptember 26, 2020 8:23 am

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Voice is not heard???Posted onSeptember 26, 2020 8:14 am

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What do you think about media contamination by cumulus and skin cells. Does genetic lab to check STRs with parents for detection of contamination?Posted onSeptember 26, 2020 8:13 am

i have no sound or picture. Trying on laptop no.2 Posted onSeptember 26, 2020 8:13 am

May we know if we are in with a sign?!Posted onSeptember 26, 2020 7:53 am

Testing question Posted onSeptember 26, 2020 7:22 am

hi.why not started? Posted onSeptember 26, 2020 7:17 am

hello newPosted onSeptember 26, 2020 7:16 am

We will begin shortly Posted onSeptember 26, 2020 7:07 am

Not getting connected Posted onSeptember 26, 2020 6:15 am

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HiPosted onSeptember 26, 2020 5:05 am

What is the best time for second trimester screening?Posted onSeptember 26, 2020 4:58 am

What is the timing of second trimester screen ing?Posted onSeptember 26, 2020 4:48 am

testing Posted onSeptember 25, 2020 8:59 pm

this is a queiostn Posted onSeptember 25, 2020 8:55 pm

tttPosted onSeptember 25, 2020 7:23 pm

testing......Posted onSeptember 25, 2020 7:22 pm

hoiPosted onSeptember 25, 2020 7:18 pm

hiPosted onSeptember 25, 2020 7:16 pm

ooopsPosted onSeptember 25, 2020 7:13 pm

againPosted onSeptember 25, 2020 7:13 pm

got herePosted onSeptember 25, 2020 7:12 pm

hi againPosted onSeptember 25, 2020 6:56 pm

shalomPosted onSeptember 25, 2020 6:56 pm

Hi guysPosted onSeptember 25, 2020 6:53 pm

HelloPosted onSeptember 25, 2020 6:52 pm

hello this is a testPosted onSeptember 25, 2020 6:52 pm

hiiiiiPosted onSeptember 25, 2020 6:38 pm

hiiiiiiPosted onSeptember 25, 2020 6:35 pm

Testing123Posted onSeptember 25, 2020 6:35 pm

hryyyyPosted onSeptember 25, 2020 6:33 pm

1 morePosted onSeptember 25, 2020 6:33 pm